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Alcohol and tranquilizer (benzodiazepines, barbiturates, sleep aids) withdrawal can cause the most serious side effects (seizures, hallucinations, heart attack, stroke, delirium tremens). Phenobarbital is a barbiturate, clonazepam is a benzodiazepine, and alcohol is well, alcohol. Folate and niacin are water soluble vitamins that will eliminate through urine and cannot become toxic.
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