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- Boric acid
Pseudoephedrine/triprolidine (Sudafed) is a good OTC treatment for sinus congestion. It is a decongestant and antihistamine combination. Diphenhydramine (Benadryl) is an antihistamine only. Amoxicillin is an antibiotic that requires a prescription. Boric acid is used to treat fungus or bacterial infections.
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